PT - JOURNAL ARTICLE AU - ANASTASIA STAVROPOULOU AU - ANASTASSIOS PHILIPPOU AU - ANTONIOS HALAPAS AU - ANTIGONE SOURLA AU - NIKOLAOS PISSIMISSIS AU - MICHAEL KOUTSILIERIS TI - uPA, uPAR and TGFβ<sub>1</sub> Expression during Early and Late Post Myocardial Infarction Period in Rat Myocardium DP - 2010 Sep 01 TA - In Vivo PG - 647--652 VI - 24 IP - 5 4099 - http://iv.iiarjournals.org/content/24/5/647.short 4100 - http://iv.iiarjournals.org/content/24/5/647.full SO - In Vivo2010 Sep 01; 24 AB - The expression patterns of transforming growth factor beta 1 (TGFβ1), urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) were analysed after artery ligation-induced myocardial infarction (MI) in the rat myocardium. uPA and uPAR expressions were significantly increased both at transcriptional and protein level during early phase post MI period (uPA at 1 hour and uPAR at 24 hours post infarction). TGFβ1 mRNA expression profile revealed a significant increase of TGFβ1 expression from day 4 up to 8 weeks post infarction. These data suggest that the need for an increasing TGFβ1 bioavailability during the post-infarction period in rat myocardium is achieved in the early post MI period by an increased expression of uPA/uPAR proteolytic system (indirect activation of latent TGFβ1) and in the late post MI period by direct regulation of TGFβ1 expression. It is therefore concluded that differential regulation of the TGFβ1 bioavailability may be a crucial step of the repair mechanisms during the post MI infarction period in the rat myocardium.