PT  - JOURNAL ARTICLE
AU  - OTTO KALLIOKOSKI
AU  - KLAS S.P. ABELSON
AU  - JANNE KOCH
AU  - ANNA BOSCHIAN
AU  - SARAH F. THORMOSE
AU  - NATASHA FAUERBY
AU  - RUNE S. RASMUSSEN
AU  - FLEMMING F. JOHANSEN
AU  - JANN HAU
TI  - The Effect of Voluntarily Ingested Buprenorphine on Rats Subjected to Surgically Induced Global Cerebral Ischaemia
DP  - 2010 Sep 01
TA  - In Vivo
PG  - 641--646
VI  - 24
IP  - 5
4099  - http://iv.iiarjournals.org/content/24/5/641.short
4100  - http://iv.iiarjournals.org/content/24/5/641.full
SO  - In Vivo2010 Sep 01; 24
AB  - The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.