PT  - JOURNAL ARTICLE
AU  - HIROSHI SAKAGAMI
AU  - TOMOHIKO MATSUTA
AU  - KAZUE SATOH
AU  - SUMIKO OHTSUKI
AU  - CHIYAKO SHIMADA
AU  - TAISEI KANAMOTO
AU  - SHIGEMI TERAKUBO
AU  - HIDEKI NAKASHIMA
AU  - YURIKA MORITA
AU  - ATSUKO OHKUBO
AU  - TADASHI TSUDA
AU  - KATSUYOSHI SUNAGA
AU  - JUN MAKI
AU  - TOMOKO SUGIURA
AU  - MADOKA KITAJIMA
AU  - HIROSHI OIZUMI
AU  - TAKAAKI OIZUMI
TI  - Biological Activity of SE-10, Granulated Powder of <em>Sasa senanensis</em> Rehder Leaf Extract
DP  - 2012 May 01
TA  - In Vivo
PG  - 411--418
VI  - 26
IP  - 3
4099  - http://iv.iiarjournals.org/content/26/3/411.short
4100  - http://iv.iiarjournals.org/content/26/3/411.full
SO  - In Vivo2012 May 01; 26
AB  - Background: We have previously reported that alkaline extract of Sasa senanensis leaves (SE) showed potent anti-HIV, anti-UV and radical scavenging activity. In the present study, we investigated the biological activities of SE-10, a granulated powder of SE supplemented with lactose, lactitol, trehalose and tea extract. Materials and Methods: Cell viability of mock-infected, HIV-infected, and UV-irradiated cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Scavenging activity of superoxide anion and hydroxyl radicals was determined by electron-spin resonance spectroscopy. Cytochrome P-450 (CYP)3A4 activity was measured by β-hydroxylation of testosterone in human recombinant CYP3A4. Results: SE-10 had slightly higher anti-HIV and anti-UV activities, but slightly lower radical-scavenging and CYP3A4-inhibitory activities, as compared with SE. Conclusion: The present study demonstrates that the biological activities of SE were well preserved during the manufacturing process of SE-10.