TY - JOUR T1 - Biological Activity of SE-10, Granulated Powder of <em>Sasa senanensis</em> Rehder Leaf Extract JF - In Vivo JO - In Vivo SP - 411 LP - 418 VL - 26 IS - 3 AU - HIROSHI SAKAGAMI AU - TOMOHIKO MATSUTA AU - KAZUE SATOH AU - SUMIKO OHTSUKI AU - CHIYAKO SHIMADA AU - TAISEI KANAMOTO AU - SHIGEMI TERAKUBO AU - HIDEKI NAKASHIMA AU - YURIKA MORITA AU - ATSUKO OHKUBO AU - TADASHI TSUDA AU - KATSUYOSHI SUNAGA AU - JUN MAKI AU - TOMOKO SUGIURA AU - MADOKA KITAJIMA AU - HIROSHI OIZUMI AU - TAKAAKI OIZUMI Y1 - 2012/05/01 UR - http://iv.iiarjournals.org/content/26/3/411.abstract N2 - Background: We have previously reported that alkaline extract of Sasa senanensis leaves (SE) showed potent anti-HIV, anti-UV and radical scavenging activity. In the present study, we investigated the biological activities of SE-10, a granulated powder of SE supplemented with lactose, lactitol, trehalose and tea extract. Materials and Methods: Cell viability of mock-infected, HIV-infected, and UV-irradiated cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Scavenging activity of superoxide anion and hydroxyl radicals was determined by electron-spin resonance spectroscopy. Cytochrome P-450 (CYP)3A4 activity was measured by β-hydroxylation of testosterone in human recombinant CYP3A4. Results: SE-10 had slightly higher anti-HIV and anti-UV activities, but slightly lower radical-scavenging and CYP3A4-inhibitory activities, as compared with SE. Conclusion: The present study demonstrates that the biological activities of SE were well preserved during the manufacturing process of SE-10. ER -