RT Journal Article SR Electronic T1 Efficacy of a Proapoptotic Peptide towards Cancer Cells JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 419 OP 426 VO 26 IS 3 A1 CLARA E. JÄKEL A1 KAROLINE MESCHENMOSER A1 YOUNG KIM A1 HANS WEIHER A1 INGO G.H. SCHMIDT-WOLF YR 2012 UL http://iv.iiarjournals.org/content/26/3/419.abstract AB Background: Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest. Materials and Methods: On this respect, we tested the antimicrobial peptide (KLAKLAK)2. Results: This peptide exhibits cytotoxicity against human breast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo. Conclusion: Our data suggest a potential use of (KLAKLAK)2 peptide for patients with breast and other types of cancer.