TY - JOUR T1 - Comparative Study of Biological Activity of Three Commercial Products of <em>Sasa senanensis</em> Rehder Leaf Extract JF - In Vivo JO - In Vivo SP - 259 LP - 264 VL - 26 IS - 2 AU - HIROSHI SAKAGAMI AU - SHOKO IWAMOTO AU - TOMOHIKO MATSUTA AU - KAZUE SATOH AU - CHIYAKO SHIMADA AU - TAISEI KANAMOTO AU - SHIGEMI TERAKUBO AU - HIDEKI NAKASHIMA AU - YURIKA MORITA AU - ATSUKO OHKUBO AU - TADASHI TSUDA AU - KATSUYOSHI SUNAGA AU - MADOKA KITAJIMA AU - HIROSHI OIZUMI AU - TAKAAKI OIZUMI Y1 - 2012/03/01 UR - http://iv.iiarjournals.org/content/26/2/259.abstract N2 - Background: We have previously reported that alkaline extract of Sasa senanensis leaves (SE) has several biological activities characteristic of lignin-carbohydrate complex (LCC). In the present study, we compared the biological activity of three commercially available products of SE (products A, B and C). Materials and Methods: Cell viability of mock-infected, HIV-infected, UV-irradiated cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Radical intensity was determined by electron spin resonance spectroscopy. Cytochrome P-450 (CYP)3A4 activity was measured by β-hydroxylation of testosterone in human recombinant CYP3A4. Results: Product A is a pure SE that contains Fe(II)-chlorophyllin, whereas products B and C contain Cu(II)-chlorophyllin and less LCC. Product C is supplemented with ginseng and pine (Pinus densiflora) leaf extracts. Product A exhibited 5-fold higher anti-HIV, 4-fold higher anti-UV, 5-fold higher hydroxyl radical-scavenging, and 3-fold lower CYP3A4 inhibitory activities as compared to those of product B, and 5-fold higher, 1.5-fold higher, comparable, and 7-fold lower activities, respectively, as compared to those of product C. Conclusion: The present study demonstrates for the first time the superiority of product A over products B and C, suggesting the beneficial role of LCC and Fe(II)-chlorophyllin. ER -