RT Journal Article
SR Electronic
T1 Muscle Regeneration: Cellular and Molecular Events
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 779
OP 796
VO 23
IS 5
A1 MARIA KARALAKI
A1 SOFIA FILI
A1 ANASTASSIOS PHILIPPOU
A1 MICHAEL KOUTSILIERIS
YR 2009
UL http://iv.iiarjournals.org/content/23/5/779.abstract
AB Muscle injury induces strong changes in muscle cells and extracellular matrix. Muscle regeneration after injury has similarities to muscle development during embryogenesis and seems to follow the same procedure. The initial phase of muscle repair is characterized by inflammation and degeneration of the damaged tissue. Almost simultaneously, previous quiescent myogenic cells, called satellite cells, are activated, proliferate, differentiate and fuse to form multinucleated myofibers. Other non-muscle stem cells may also take part in this process. Secreted factors, such as hepatocyte growth factor (HGF), fibroblast growth factors (FGFs), transforming growth factor-βs (TGF-βs), insulin-like growth factors (IGFs), tumour necrosis factor α (TNFα) and others, are released during muscle repair and guide muscle regeneration, however, their exact functions and effects on muscle remodeling remain unknown. Intensive research is currently addressing the regenerative mechanisms which are involved in acute muscle injuries and chronic muscle diseases.