@article {CHANG755, author = {YUNG-HSIEN CHANG and JAI-SING YANG and JIUN-LONG YANG and CHANG-LIN WU and SHU-JEN CHANG and KUNG-WEN LU and CHAO-LIN KUO and TE-CHUN HSIA and JING-GUNG CHUNG}, title = {Gandoderma lucidum Extract Promotes Immune Responses in Normal BALB/c Mice In Vivo}, volume = {23}, number = {5}, pages = {755--759}, year = {2009}, publisher = {International Institute of Anticancer Research}, abstract = {Enhanced fruit and vegetable consumption is closely related to reduced cancer incidence as shown in epidemiological studies. Ganoderma lucidum, one of the most well-known traditional Chinese medicines, has been demonstrated to have pharmacological activities and antitumor effects, in Asian populations. However, the promotion of immune responses in normal BALB/c mice is unclear. In the present study, we investigated the immune responses of BALB/c mice after treatment with G. lucidum extract in vivo. The results demonstrated that G. lucidum extract was able to promote the proliferation of splenocytes under Concanavalin A or lipopolysaccharide stimulation. Compared with the control group, phagocytosis of macrophage was significantly enhanced by intraperitoneal administration of G. lucidum extract at both 3 and 6 mg/kg. Compared with the control group, natural killer cell activity was significantly enhanced by intraperitoneal administration of G. lucidum extract (6 mg/kg). Results of cytometric bead array and flow cytometry indicated that the expressions of interleukin-6 and interferon-γ also increased (p\<0.001) by treatment with G. lucidum extract (3 and 6 mg/kg). In conclusion, the findings of this study implied that G. lucidum extract was able to effectively promote immune responses in BALB/c mice.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/23/5/755}, eprint = {https://iv.iiarjournals.org/content/23/5/755.full.pdf}, journal = {In Vivo} }