RT Journal Article
SR Electronic
T1 Hepatoprotection of Chlorella against Carbon Tetrachloride-induced Oxidative Damage in Rats
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 747
OP 754
VO 23
IS 5
A1 HSIN-YI PENG
A1 YU-CHAN CHU
A1 SHU-JU CHEN
A1 SU-TZE CHOU
YR 2009
UL http://iv.iiarjournals.org/content/23/5/747.abstract
AB The effects of 80% ethanolic chlorella extracts (GPE) on carbon tetrachloride (CCl4)-induced hepatic damage were investigated in Sprague-Dawley rats. The rats were orally treated with GPE (0.5 g/kg body weight) or silymarin (0.2 g/kg body weight) over four consecutive weeks with administration of CCl4 (20% CCl4, 0.5 ml/rat twice a week). The GPE had a significant protective effect against liver injuries, as well as oxidative stress induced by CCl4, resulting in reduced lipid peroxidation and improved serum biochemical parameters such as aspartate aminotransferase and alanine aminotransferase. The reduced levels of glutathione, vitamin C, superoxide dismutase, and catalase in the CCl4-treated rats were significantly increased by treatment with GPE. Furthermore, the activity of GPE was comparable to the standard drug silymarin. In conclusion, chlorella may be useful as a hepatoprotective agent against chemical-induced liver damage in vivo.