TY - JOUR T1 - Excisional Breast Biopsy Under Local Anesthesia: Stress-related Neuroendocrine, Metabolic and Immune Reactions During the Procedure JF - In Vivo JO - In Vivo SP - 649 LP - 652 VL - 23 IS - 4 AU - GEORGE C. ZOGRAFOS AU - FLORA ZAGOURI AU - THEODOROS N. SERGENTANIS AU - GEORGIA GIANNAKOPOULOU AU - XENI PROVATOPOULOU AU - ELENI KALOGERA AU - CHRISTOS PAPADIMITRIOU AU - GEORGE FILIPPAKIS AU - ALEXANDROS SAGKRIOTIS AU - JOHN BRAMIS AU - ANTONIA GOUNARIS Y1 - 2009/07/01 UR - http://iv.iiarjournals.org/content/23/4/649.abstract N2 - Aim: The aim of this study was to evaluate three axes: the sympathetic system (adrenaline and noradrenaline), surgical stress-related endocrine factors (prolactin, cortisol, insulin, glucose and growth hormone) and inflammatory cytokines (IL-1α, IL-1β and IL-6) during excisional breast biopsy under local anesthesia (EBBLA). Patients and Methods: On 14 women undergoing EBBLA, all the aforementioned molecules were measured in peripheral venous blood samples prior (baseline), during (at 10 and 30 minutes), at the end of EBBLA (46±9 minutes) and one hour after its end. Results: Serum growth hormone glucose and cortisol were found elevated at the 10th and 30th minute and at the end of EBBLA. Serum prolactin increased only at the 30th minute. Of notice, none of the measured parameters was found elevated one hour after the end of biopsy. Concerning adrenaline, noradrenaline and interleukins, no significant changes were documented. Conclusion: During EBBLA, significant stress-related endocrine events arise. However, no significant sympathetic / cytokine triggering was noted. ER -