<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">HOORNSTRA, DOUWE</style></author><author><style face="normal" font="default" size="100%">VESTERLIN, JENNI</style></author><author><style face="normal" font="default" size="100%">PÄRNÄNEN, PIRJO</style></author><author><style face="normal" font="default" size="100%">AL-SAMADI, AHMED</style></author><author><style face="normal" font="default" size="100%">ZLOTOGORSKI-HURVITZ, AYELET</style></author><author><style face="normal" font="default" size="100%">VERED, MARILENA</style></author><author><style face="normal" font="default" size="100%">SALO, TUULA</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion &lt;em&gt;In Vitro&lt;/em&gt; Similarly to Curcumin</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-09-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1089-1095</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/invivo.11350</style></doi><volume><style face="normal" font="default" size="100%">32</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Oral tongue squamous cell carcinoma (OTSCC) cells are highly proliferative and invasive. Lingonberry contains several polyphenolic compounds similar to curcumin. We hypothesize that fermented lingonberry juice (FLJ) has an anti-invasive and anti-proliferative effect on OTSCC cells similarly to curcumin, which is known to be anti-carcinogenic. Materials and Methods: FLJ, curcumin dissolved in ethanol, or curcumin loaded in Candida extracellular vesicles (EVs) were added to more (HSC-3) and less aggressive (SCC-25) OTSCC cells. Cell proliferation was measured with a 5-bromo-2’-deoxyuridine kit and invasion in the three-dimensional Myogel spheroid assay. Statistical analyses were completed with one-way ANOVA and Bonferroni post-hoc testing. Results: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells. The effects of curcumin were not improved when cells were treated with curcumin loaded within EVs. Conclusion: Our results suggest that FLJ, like curcumin, has an anti-carcinogenic effect on aggressive OTSCC cells in vitro.</style></abstract></record></records></xml>