@article {IVANOVA545, author = {ANTOANETA IVANOVA and JULIANNA SERLY and DRAGOMIR DINCHEV and IMRE OCSOVSZKI and IVANKA KOSTOVA and JOSEPH MOLNAR}, title = {Screening of Some Saponins and Phenolic Components of Tribulus terrestris and Smilax excelsa as MDR Modulators}, volume = {23}, number = {4}, pages = {545--550}, year = {2009}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line. Materials and Methods: Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. Results: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 μg/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. Conclusion: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/23/4/545}, eprint = {https://iv.iiarjournals.org/content/23/4/545.full.pdf}, journal = {In Vivo} }