TY - JOUR T1 - Gallic Acid Inhibits Murine Leukemia WEHI-3 Cells <em>In Vivo</em> and Promotes Macrophage Phagocytosis JF - In Vivo JO - In Vivo SP - 409 LP - 413 VL - 23 IS - 3 AU - CHIN-CHIN HO AU - SHUW-YUAN LIN AU - JAI-SING YANG AU - KUO-CHING LIU AU - YIH-JING TANG AU - MEI-DUE YANG AU - JO-HUA CHIANG AU - CHI-CHENG LU AU - CHANG-LIN WU AU - TSAN-HUNG CHIU AU - JING-GUNG CHUNG Y1 - 2009/05/01 UR - http://iv.iiarjournals.org/content/23/3/409.abstract N2 - Gallic acid is a polyhydroxyphenolic compound which can be found in various natural products. It is recognized to be an excellent free radical scavenger and has been shown to induce apoptosis in lung cancer and leukemia cells. No report has addressed whether gallic acid affects mouse leukemia cells in vivo. In this study, we examined the in vivo effects of gallic acid on leukemia WEHI-3 cells and on macrophage phagocytosis. Gallic acid caused a significant decrease in the weights of the spleens and livers from BALB/c mice. One of the major characteristic of WEHI-3 leukemia is the enlarged spleen in mice after i.p. injection of WEHI-3 cells. Gallic acid did not affect the percentages of CD3, CD11 and CD19 markers but decreased the percentage of Mac-3 in a high-dose (80 mg/kg) treatment while promoting Mac-3 levels in a low-dose (40 mg/kg) treatment. Gallic acid promoted the activity of macrophage phagocytosis in the white blood cells from peripheral blood mononuclear cells (PBMCs) at 40 and 80 mg/kg treatment doses, but decreased the macrophage phagocytosis in isolated peritoneal cells at the 80 mg/kg dose. ER -