RT Journal Article SR Electronic T1 Tension-free Primary Closure with Autologous Platelet Gel versus Vivostat− for the Definitive Treatment of Chronic Sacrococcygeal Pilonidal Disease JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 583 OP 589 VO 24 IS 4 A1 MARCO GIPPONI A1 GIULIANO REBOA A1 TOMMASO TESTA A1 GABRIELLA GIANNINI A1 PAOLO STRADA YR 2010 UL http://iv.iiarjournals.org/content/24/4/583.abstract AB Objective: A randomized clinical trial was performed in patients with chronic or recurrent pilonidal sinus (PS) comparing primary closure coupled with random application of in house autologous platelet gel or produced by means of Vivostat− in order to assess whether a standardized product had an impact on the wound healing process. Patients and Methods: Between June 2006 and June 2009, 100 patients (82 males, 18 females: median age 30 years; range, 16-51 years) underwent wide excision of the pilonidal area with midline tension-free closure and were randomly given either the in house autologous platelet gel (Group 1) or the Vivostat− gel (Group 2). Results: Group 2 patients had shorter wound healing time (8 vs. 10 days; p<0.0001), time to return to full activity (11 vs. 16 days: p<0.0001), less uncomplicated fluid collections (120 vs. 190 ml: p<0.0001), and fewer postoperative wound complications (1/50=2% vs. 5/50=10%, p<0.001). After a median follow-up of 21 months (range: 4-40 months), two recurrences were detected in Group 1. Conclusion: The standardized production of platelet gel by means of the Vivostat− system guarantees the reproducibility of the procedure and its use was correlated with an improved outcome, with a high degree of patient satisfaction and better cosmetic results.