<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">GETOFF, NIKOLA</style></author><author><style face="normal" font="default" size="100%">SCHITTL, HEIKE</style></author><author><style face="normal" font="default" size="100%">HARTMANN, JOHANNES</style></author><author><style face="normal" font="default" size="100%">GERSCHPACHER, MARION</style></author><author><style face="normal" font="default" size="100%">YING, SHAOBIN</style></author><author><style face="normal" font="default" size="100%">DANIELOVA, IREN</style></author><author><style face="normal" font="default" size="100%">HUBER, JOHANNES C.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Mutual Interaction of 17β-Estradiol and Progesterone: Electron Emission. Free Radical Effect Studied by Experiments &lt;em&gt;In Vitro&lt;/em&gt;</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2010-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">535-541</style></pages><volume><style face="normal" font="default" size="100%">24</style></volume><issue><style face="normal" font="default" size="100%">4</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Based on the different behaviour of 17β-estradiol (17βE2) and progesterone (PRG), it was of interest to investigate the interaction of both hormones in respect of their electron emission and cytotoxicity by experiments in vitro. Materials and Methods: The studies include determination of emitted electrons (e−aq) by the individual hormones as well as by their mixtures, all complexed with cyclodextrin (HBC). Experiments in vitro (Escherichia coli bacteria) were performed for a better understanding of the mechanisms involved. Survival ratios, ΔD37(Gy), were calculated. Results: Aqueous HBC as well as 17βE2 and PRG, individually as well as in mixtures, are able to emit e−aq. The resulting transients can lead to the formation of metabolites, some of which can initiate cancer. It was established that both hormones, 17βE2 and PRG, interact in respect to their electron emission property. In the frame of experiments in vitro, it was found that oxidizing radicals (OH, O2•−) lead to negative ΔD37(Gy) values, indicating cytostatic properties. On the other hand, the primary reducing radicals (e−aq, H) lead to positive ΔD37(Gy) values, indicating a radical-scavenging effect. Conclusion: The main outcome of this work is that PRG in combination with 17βE2 can strongly reduce the number of carcinogenic 17βE2-metabolites. This fact offers a new pathway for application of hormones in medical treatment of patients.</style></abstract></record></records></xml>