RT Journal Article
SR Electronic
T1 Concentrations of Inflammatory Cytokines and the Outcome in ICSI Cycles
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 495
OP 500
VO 24
IS 4
A1 ASIMAKOPOULOS, BYRON
A1 DEMIREL, CEM
A1 FELBERBAUM, RICARDO
A1 WACZEK, STEVEN
A1 NIKOLETTOS, NIKOS
A1 KÖSTER, FRANK
A1 AL-HASANI, SAFAA
A1 DIEDRICH, KLAUS
YR 2010
UL http://iv.iiarjournals.org/content/24/4/495.abstract
AB The aim of this study was to measure circulating and intrafollicular concentrations of three inflammatory cytokines from women undergoing ovarian stimulation in order to determine their prognostic value in the outcome of intracytoplasmic sperm injection/embryo transfer cycles. Materials and Methods: A total of 72 women following ovarian stimulation and intracytoplasmic sperm injection were included. Blood serum samples were drawn at the day of chorionic gonadotropin administration. Follicular fluids were collected at the day of oocyte retrieval. The total fractions of tumor necrosis factor α, interleukin (IL)-1β and IL-6 were measured with commercially available immunoassays. Results: The concentrations of IL-1β, both in serum and follicular fluids, were significantly different between ICSI cycles that resulted in pregnancy and those that failed. The concentrations of the other two cytokines did not significantly differ between successful and unsuccessful cycles. Conclusion: The circulating and intrafollicular concentrations of IL-1β seem to be related to the pregnancy outcome in ICSI cycles of healthy women.