RT Journal Article SR Electronic T1 Effect of Atorvastatin on Cellular Adhesion Molecules on Leukocytes in Patients with Normocholesterolemic Coronary Artery Disease JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 189 OP 193 VO 24 IS 2 A1 THOMAS WALTER A1 TIM SUSELBECK A1 MARTIN BORGGREFE A1 STEFANIE SWOBODA A1 HANS MARTIN HOFFMEISTER A1 CARL-ERIK DEMPFLE YR 2010 UL http://iv.iiarjournals.org/content/24/2/189.abstract AB Background: Expression of cellular adhesion molecules on leukocytes plays a key role in coronary artery disease (CAD). The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD. Patients and Methods: In 54 patients with CAD and atorvastatin treatment and 54 CAD patients without atorvastatin therapy, expression of CD40L, CD11a, CD11b, CD54, CD62L and CD41 on leukocytes was measured using flow cytometry. All patients were normocholesterolemic. Results: Atorvastatin treatment led to a significantly lower expression of CD40L, CD11b and CD54 on monocytes (p<0.05) and neutrophils (p<0.05). Expression of CD11a was significantly lower on monocytes (p<0.05) in atorvastatin-treated patients. Conclusion: The present results indicate that atorvastatin apparently improves chronic inflammation and may have a beneficial effect on hemostasis by reducing the expression of cellular adhesion molecules on leukocytes. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved