PT  - JOURNAL ARTICLE
AU  - THOMAS WALTER
AU  - TIM SUSELBECK
AU  - MARTIN BORGGREFE
AU  - STEFANIE SWOBODA
AU  - HANS MARTIN HOFFMEISTER
AU  - CARL-ERIK DEMPFLE
TI  - Effect of Atorvastatin on Cellular Adhesion Molecules on Leukocytes in Patients with Normocholesterolemic Coronary Artery Disease
DP  - 2010 Mar 01
TA  - In Vivo
PG  - 189--193
VI  - 24
IP  - 2
4099  - http://iv.iiarjournals.org/content/24/2/189.short
4100  - http://iv.iiarjournals.org/content/24/2/189.full
SO  - In Vivo2010 Mar 01; 24
AB  - Background: Expression of cellular adhesion molecules on leukocytes plays a key role in coronary artery disease (CAD). The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD. Patients and Methods: In 54 patients with CAD and atorvastatin treatment and 54 CAD patients without atorvastatin therapy, expression of CD40L, CD11a, CD11b, CD54, CD62L and CD41 on leukocytes was measured using flow cytometry. All patients were normocholesterolemic. Results: Atorvastatin treatment led to a significantly lower expression of CD40L, CD11b and CD54 on monocytes (p<0.05) and neutrophils (p<0.05). Expression of CD11a was significantly lower on monocytes (p<0.05) in atorvastatin-treated patients. Conclusion: The present results indicate that atorvastatin apparently improves chronic inflammation and may have a beneficial effect on hemostasis by reducing the expression of cellular adhesion molecules on leukocytes. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved