PT - JOURNAL ARTICLE AU - GIUSEPPINA MESSINA AU - PAOLO LISSONI AU - ERIO BARTOLACELLI AU - LUCIANO MAGOTTI AU - MASSIMO CLERICI AU - PAOLO MARCHIORI AU - ELISA COLOMBO TI - Relationship between Psychoncology and Psychoneuroendocrinoimmunology (PNEI): Enhanced T-Regulatory Lymphocyte Activity in Cancer Patients with Self-punishement, Evaluated by Rorschach Test DP - 2010 Jan 01 TA - In Vivo PG - 75--78 VI - 24 IP - 1 4099 - http://iv.iiarjournals.org/content/24/1/75.short 4100 - http://iv.iiarjournals.org/content/24/1/75.full SO - In Vivo2010 Jan 01; 24 AB - Background: Psychological studies have documented the presence of a self-punishment profile in cancer patients. Recent immuno-oncological studies have shown that within the group of CD4+ cells, which play a fundamental role in the generation of anticancer immunity, there is a subtype of cells that in contrast mediates the suppression of the anticancer immunity, the so-called T-regulatory cells (T-reg), which may be identified as CD4+CD25+ cells. Patients and Methods: On this basis, we performed a psychoncological study to evaluate CD4+CD25+ cell numbers in relation to the response to Rorschach's test in a group of 30 cancer patients suffering from the most frequent tumor histotypes. Results: Normal values obtained in our laboratory (95% confidence limits) of T-reg lymphocytes and CD4+/CD4+CD25+ were <240/mm3 and >4mm3, respectively. The psychological profile of self-punishment was found in 18/30 patients (60%). The percentage of patients with abnormally high CD4+CD25+ values observed in the group with self-punishment was significantly higher than that found in patients without self punishment (11/18 vs. 3/12 (25%), p<0.05). In the same way, the percentage of patients with abnormally low CD4+/CD4+CD25+ ratios was significantly higher in the group with self-punishment (16/18 vs. 4/12, p<0.01). The mean numbers of T-reg lymphocytes observed in the group with self-punishment was significantly higher than that found in patients who had no self-punishment (314±39 vs. 173±27, p<0.05). In addition, the mean CD4+/ CD4+CD25+ ratio was significantly lower in patients with self-punishment than in the other group (2.6±0.2 vs. 5.2±0.8, p<0.025). On the contrary, no significant difference was seen in the mean number of CD4+ lymphocytes. Conclusion: The study suggests that self-punishment may inhibit the generation of an effective anticancer immune response by stimulating the activation and proliferation of T-reg lymphocytes, which in turn stimulate tumor dissemination by suppressing anticancer immunity. The abnormally high number of T-reg lymphocytes in patients with self-punishment would suggest a specific immune alteration, as suggested by the evidence of a normal profile for other immune parameters, such as total CD4+ lymphocytes. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved