RT Journal Article
SR Electronic
T1 Comparison of the Effect of Orally Administered Soluble β-(1-3),(1-6)-D-Glucan and of G-CSF on the Recovery of Murine Hematopoiesis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 59
OP 63
VO 24
IS 1
A1 ULF HARNACK
A1 KLAUS ECKERT
A1 IDUNA FICHTNER
A1 GABRIELE PECHER
YR 2010
UL http://iv.iiarjournals.org/content/24/1/59.abstract
AB β-Glucans are branched fungal polysaccharide compounds with pleiotropic activating effects on cells of the immune and the hematopoietic system. In this study, the hematopoiesis-promoting effect of an orally administered soluble β-(1-3),(1-6)-D-glucan and of intravenously (i.v.) injected recombinant human granulocyte colony-stimulating factor (G-CSF/filgrastim) was tested in cyclophosphamide (CY)-conditioned mice. Both agents were administered for 5 consecutive days following treatment with CY. When G-CSF and the carbohydrate compound were co-administered, a small but non-significant increase of granulopoiesis compared to G-CSF alone was detected. β-Glucan alone failed to augment granulopoiesis in the peripheral blood of CY-treated mice. However, both G-CSF and β-glucan significantly enhanced the recovery of monocytes in the peripheral blood of leukopenic mice when orally administered as single agents. In conclusion, the present study provides further evidence of a stimulatory function of orally administered β-glucans on monocyte production and shows a weak additive effect on granulopoiesis when co-administered with G-CSF into leukopenic mice. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved