RT Journal Article SR Electronic T1 Inhibition of Prostaglandin E2 Production by Flavone and its Related Compounds JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 55 OP 58 VO 24 IS 1 A1 TADAYOSHI KANEKO A1 HIROSHIGE CHIBA A1 NORIO HORIE A1 TAKAO KATO A1 MASAKI KOBAYASHI A1 KEN HASHIMOTO A1 KAORU KUSAMA A1 HIROSHI SAKAGAMI YR 2010 UL http://iv.iiarjournals.org/content/24/1/55.abstract AB We have previously reported that among 12 major ingredients of Sairei-to, Scutellariae radix inhibited prostaglandin E2 (PGE2) production by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells more efficiently than other ingredients, and wogonin, a major flavonoid from Scutellariae radix, showed greater inhibitory activity and membrane permeability than baicalein and baicalin. Here the effects of six other flavonoids, with similar structures, on membrane permeability and PGE2 production were investigated. 7-Methoxyflavone inhibited the LPS-stimulated PGE2 production to the greatest extent, followed by flavone>wogonin (5,7-dihydroxy-8-methoxyflavone)>> 7,8-dimethoxyflavone>chrysin (5,7-dihydroxyflavone)> baicalein (5,6,7-trihydroxyflavone)>>chromone. 7-Methoxyflavone also showed the highest membrane permeability, followed by flavone>chrysin>7,8-dimethoxy-flavone>wogonin>baicalein. When PGE2 inhibitory activity was expressed per molecule incorporated into the cells, wogonin produced the greatest inhibition, further substantiating its anti-inflammatory potency. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved