PT  - JOURNAL ARTICLE
AU  - TADAYOSHI KANEKO
AU  - HIROSHIGE CHIBA
AU  - NORIO HORIE
AU  - TAKAO KATO
AU  - MASAKI KOBAYASHI
AU  - KEN HASHIMOTO
AU  - KAORU KUSAMA
AU  - HIROSHI SAKAGAMI
TI  - Inhibition of Prostaglandin E<sub>2</sub> Production by Flavone and its Related Compounds
DP  - 2010 Jan 01
TA  - In Vivo
PG  - 55--58
VI  - 24
IP  - 1
4099  - http://iv.iiarjournals.org/content/24/1/55.short
4100  - http://iv.iiarjournals.org/content/24/1/55.full
SO  - In Vivo2010 Jan 01; 24
AB  - We have previously reported that among 12 major ingredients of Sairei-to, Scutellariae radix inhibited prostaglandin E2 (PGE2) production by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells more efficiently than other ingredients, and wogonin, a major flavonoid from Scutellariae radix, showed greater inhibitory activity and membrane permeability than baicalein and baicalin. Here the effects of six other flavonoids, with similar structures, on membrane permeability and PGE2 production were investigated. 7-Methoxyflavone inhibited the LPS-stimulated PGE2 production to the greatest extent, followed by flavone>wogonin (5,7-dihydroxy-8-methoxyflavone)>> 7,8-dimethoxyflavone>chrysin (5,7-dihydroxyflavone)> baicalein (5,6,7-trihydroxyflavone)>>chromone. 7-Methoxyflavone also showed the highest membrane permeability, followed by flavone>chrysin>7,8-dimethoxy-flavone>wogonin>baicalein. When PGE2 inhibitory activity was expressed per molecule incorporated into the cells, wogonin produced the greatest inhibition, further substantiating its anti-inflammatory potency. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved