RT Journal Article
SR Electronic
T1 Effectiveness of Combined Modality Radiotherapy of Orthotopic Human Squamous Cell Carcinomas in Nu/Nu Mice Using Cetuximab, Tirapazamine and MnSOD-Plasmid Liposome Gene Therapy
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1
OP 8
VO 24
IS 1
A1 MICHAEL W. EPPERLY
A1 STEPHEN Y. LAI
A1 ANTHONY J. KANAI
A1 NEAL MASON
A1 BRIAN LOPRESI
A1 TRACEY DIXON
A1 DARCY FRANICOLA
A1 YUNYUN NIU
A1 WILLIAM R. WILSON
A1 JOEL S. GREENBERGER
YR 2010
UL http://iv.iiarjournals.org/content/24/1/1.abstract
AB Hypoxic regions limit the radiocontrollability of head and neck carcinomas. Whether or not combinations of plasmid/liposome mediated overexpression of normal tissue protective manganese superoxide dismutase (MnSOD), cetuximab (C225), and the hypoxic cytotoxin tirapazamine (TPZ) enhanced radiotherapeutic effects was tested in a CAL-33 orthotopic mouse cheek tumor model. The tumor volume continued to increase in the control (untreated) mice, with a ninefold increase by 10 days when the tumors exceeded 2 cm3. The mice receiving 14 Gy only showed reduced tumor growth to 3.1±0.1 fold at day 10. The mice receiving MnSOD-PL, C225, TPZ plus 14 Gy had the best outcome with 0.7±0.1 fold increase in tumor volume by 10 days (p=0.015) compared to irradiation only. The addition of MnSOD-PL, TPZ, and C225 to irradiation optimized the therapeutic ratio for the local control of hypoxic region-containing CAL-33 orthotopic tumors. Copyright © 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved