<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">RUBIO, CARLOS A.</style></author><author><style face="normal" font="default" size="100%">MILLER, MARIAN L.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Fundic Gland Cysts in &lt;em&gt;Atp4a&lt;/em&gt;&lt;sup&gt;−/−&lt;/sup&gt; Mice Mimic Fundic Gland Polyps in Humans</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">979-981</style></pages><volume><style face="normal" font="default" size="100%">23</style></volume><issue><style face="normal" font="default" size="100%">6</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Innumerable fundic gland polyps (FGPs) (that is massive FGP polyposis) may be found in the human stomach. Innumerable fundic gland cysts (FGCs) develop in mice lacking the gene Atp4a (Atp4a(−/−)), that encodes the enzyme ATPase. The aim was to monitor the evolution of FGCs in Atp4a(−/−) mice. Materials and Methods: Six pairs (male-female) of Atp4a(−/−) mice, 8, 12 and 20 months old, were investigated. Wild-type Atp4a(+/+) mice were used as controls. Results: In Atp4a(−/−) female mice, the mucosal thickness increased both at 8 months (943±72 mm) (p&lt;0.02) and at 12 months (p&lt;0.0008) and even further at 20 months (p&lt;0.0001). The FGC area was 13.183±7.218 mm2 at 12 months and 73.361±50.591 mm2 at 20 months (p&lt;0.0008). FGCs in Atp4a(−/−) mice were lined by parietal cells, mucous pit-foveolar cells and chief cells, thus mimicking FGPs in humans. Conclusion: Older female Atp4a(−/−) mice developed innumerable FGCs, a phenomenon very similar to massive FGPs seen in humans. In the light of these similarities, the Atp4a(−/−) mouse emerges as a suitable animal model to investigate the series of events taking place during the evolution of FGPs in humans.</style></abstract></record></records></xml>