RT Journal Article SR Electronic T1 The Plant-derived Natural Compound Flavin 7® Attenuates Oxidative Stress in Cultured Renal Proximal Tubule Cells JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 975 OP 978 VO 23 IS 6 A1 EMBER, AGOSTON A1 CLARK, JEB S. A1 VARJAS, TIMEA A1 KISS, ISTVAN A1 EMBER, ISTVAN A1 BALIGA, RADHAKRISHNA A1 ARANY, ISTVAN YR 2009 UL http://iv.iiarjournals.org/content/23/6/975.abstract AB Background: Cancer therapies and cancer progression can increase oxidative stress that might account for renal toxicity in cancer patients. Flavin 7® (F7) is a natural polyphenol-containing dietary supplement with potential antioxidant activity. Therefore, it might help to attenuate renal toxicity of chemotherapeutics. Materials and Methods: Cultured mouse renal proximal tubule cells were subjected to H2O2-mediated oxidative stress. Potential antioxidant effects of F7 were assessed by measuring the production of reactive oxygen species (ROS), mitochondrial depolarization and injury (lactate dehydrogenase release as well as trypan blue exclusion) in cells that were pretreated with F7 prior to treatment with H2O2. Results: F7 pretreatment significantly attenuated H2O2-induced ROS production, mitochondrial depolarization and consequent injury in renal proximal tubule cells. Conclusion: F7 supplementation might be beneficial for cancer patients in order to prevent renal toxicity of anticancer drug- or cancer progression-related oxidative stress.