PT  - JOURNAL ARTICLE
AU  - BOONLONG, NUTTANICHA
AU  - SALANG, LINGLING
AU  - PROUNGVITAYA, SIRIPORN
AU  - MARAMING, PORNSUDA
AU  - DADUANG, JUREERUT
AU  - PONGSRITASANA, THANIDA
AU  - SUKKASAME, SINEENART
AU  - HAOHAN, SONGPOL
TI  - The Asn680Ser Variant Negatively Impacted the Ovarian Response to Controlled Ovarian Stimulation in Thai Female Infertility
AID  - 10.21873/invivo.14300
DP  - 2026 May 01
TA  - In Vivo
PG  - 1497--1508
VI  - 40
IP  - 3
4099  - http://iv.iiarjournals.org/content/40/3/1497.short
4100  - http://iv.iiarjournals.org/content/40/3/1497.full
SO  - In Vivo2026 May 01; 40
AB  - Background/Aim: The aim of this study was to evaluate the associations between three follicle-stimulating hormone receptor (FSHR) and FSH β subunit promoter gene polymorphisms, including Asn680Ser, −29G>A, and −211G>T with ovarian response, oocyte maturation, and embryo quality in Thai infertile women.Materials and Methods: A total of 78 infertile Thai women undergoing in vitro fertilization or intracytoplasmic sperm injection were recruited. The polymorphisms were analyzed using polymerase chain reaction - restriction fragments length polymorphism.Results: The Asn680Ser variant was significantly associated with ovarian response. The Asn/Asn genotype was more frequent in hyper-responders (66.7%), while the Asn/Ser genotype predominated among poor responders (71.4%, p=0.038). S-carriers combining Asn/Ser and Ser/Ser genotypes were overrepresented in the poor response group (78.6%, p=0.029). Logistic regression analysis revealed the association between Asn/Ser and S-carriers with poor response [crude odds ratio (OR)= 6.33, 95% confidence interval (CI)=1.56-25.66 and 5.36, 95% CI=1.36-21.10, respectively]. The associations remained after age adjustment (adjusted OR=7.71 95% CI=1.73-34.45 and 6.78, 95% CI=1.57-29.29, respectively). In contrast, −29G>A and −211G>T polymorphisms were not associated with ovarian response. There were not any associations between the three polymorphisms and oocytes maturation and embryo quality.Conclusion: This study is the first to report the association between Asn680Ser FSHR gene polymorphism and the risk of poor response among Thai women.