RT Journal Article
SR Electronic
T1 Management of a Complex Orbital Post-transplantation Lymphoproliferative Disorder: A Case Report and Literature Review
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1824
OP 1831
DO 10.21873/invivo.14336
VO 40
IS 3
A1 MARUYAMA, TESSHO
A1 HOKAMA, YOHEI
A1 KISHABA, KAZUTAKA
A1 KUNINAKA, TOMOMI
A1 KOBAYASHI, SHIGETAKA
A1 NAGAMINE, HIDEKI
A1 MIYAHIRA, HIROFUMI
A1 TANAKA, KEI
A1 MORICHIKA, KAZUHO
A1 KAWAKAMI, FUMI
A1 TOMITA, MARIKO
A1 WADA, NAOKI
A1 YOGI, AKIRA
A1 MASUZAKI, HIROAKI
A1 HAMASAKI, TADASHI
YR 2026
UL http://iv.iiarjournals.org/content/40/3/1824.abstract
AB Background/Aim: Post-transplantation lymphoproliferative disorder (PTLD) is an uncommon but serious complication of organ transplantation. Management often requires multiple treatment modalities and reduction in immunosuppressant treatment (RIT). Orbital involvement is rare, and optimal diagnostic and therapeutic approaches remain uncertain.Case Report: Here, we report a case of localized orbital PTLD that was successfully treated with RIT alone. A 62-year-old man, who had undergone kidney transplantation 18 years prior, presented with left eye pain and proptosis. Imaging revealed an enhancing intraorbital mass extending to the optic nerve and adjacent intracranial structures. Transcranial biopsy confirmed B-cell-type PTLD. The lesion regressed with stepwise RIT alone without additional therapy. The patient showed clear clinical improvement and remained in remission for more than 13 months.Conclusion: This case suggests the potential role of a conservative, individualized, stepwise approach in selected patients with localized orbital PTLD, and may inform management strategies for other localized forms of PTLD.