TY - JOUR T1 - Immunohistochemical Staining of Mucin 1 in Prostate Tissues JF - In Vivo JO - In Vivo SP - 203 LP - 207 VL - 23 IS - 2 AU - NADEGE RABIAU AU - PIERRE DECHELOTTE AU - LAURENT GUY AU - SAMIR SATIH AU - REMY BOSVIEL AU - LUC FONTANA AU - JEAN-LOUIS KEMENY AU - JEAN-PAUL BOITEUX AU - YVES-JEAN BIGNON AU - DOMINIQUE BERNARD-GALLON Y1 - 2009/03/01 UR - http://iv.iiarjournals.org/content/23/2/203.abstract N2 - Prostate cancer is a major public health problem in the world. Molecular studies are necessary for the development of prognostic markers in prostate cancer. There is a great interest in mucin studies in treatment development of human malignancies, including prostate cancer. Nevertheless, their expressions in prostate cancer need further investigation. Materials and Methods: Mucin 1 (MUC1) expression was examined in 100 prostate biopsies and were compared with prostate carcinoma cell lines (DU-145, PC-3, LNCaP) by immunohistochemistry. Results: Biopsies were healthy, tumor, peritumor or presented an intraepithelial neoplasia. Staining of MUC1 was exihibited in PC-3 cells, was higher in DU-145, and was not expressed by LNCaP. Tumor sections presented more positive expression of MUC1 than non-tumor sections. Conclusion: MUC1 expression is correlated with the histological degree of malignancy. ER -