PT  - JOURNAL ARTICLE
AU  - KATALIN GOMBOS
AU  - TÍMEA VARJAS
AU  - ZSUZSANNA ORSÓS
AU  - ÉVA POLYÁK
AU  - JUDIT PEREDI
AU  - ZSUZSANNA VARGA
AU  - GHODRATOLLAH NOWRASTEH
AU  - ANTAL TETTINGER
AU  - GYULA MUCSI
AU  - ISTVÁN EMBER
TI  - The Effect of Aspartame Administration on Oncogene and Suppressor Gene Expressions
DP  - 2007 Jan 01
TA  - In Vivo
PG  - 89--92
VI  - 21
IP  - 1
4099  - http://iv.iiarjournals.org/content/21/1/89.short
4100  - http://iv.iiarjournals.org/content/21/1/89.full
SO  - In Vivo2007 Jan 01; 21
AB  - Background: Aspartame (L-phenylalanine N-L-α-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene. Materials and Methods: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs. Results: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney. Conclusion: Aspartame has a biological effect even at the recommended daily maximum dose. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved