RT Journal Article
SR Electronic
T1 A Color Doppler Ultrasound-based Comparative Study between Stavudine and Non-stavudine Regimens in the Onset of Vascular Lesions in HIV-1-positive Patients
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 489
OP 492
VO 22
IS 4
A1 PAOLO MAGGI
A1 ANTONIO CHIRIANNI
A1 ANTONIO LILLO
A1 FRANCESCO PERILLI
A1 MIRIAM GARGIULO
A1 VINCENZO ESPOSITO
A1 CHIARA BELLACOSA
A1 GIUSEPPE PASTORE
A1 GUIDO REGINA
YR 2008
UL http://iv.iiarjournals.org/content/22/4/489.abstract
AB Background: The present study aimed to investigate the role of stavudine in the onset of premature vascular lesions using an ultrasound color Doppler evaluation of the carotid vessels. Patients and Methods: A total of 266 patients were evaluated: 149 were treated with stavudine (group I) and 117 without stavudine (group II). Results: Of the patients in group I, 41% exhibited vascular lesions vs. 26% in group II (p=0.0103). The two groups were further divided into subgroups Ia (stavudine and proteinase inhibitor, PI), Ib (stavudine and non-nucleotidic reverse transcriptase inhibitor, NNRTI), IIa (PI, without stavudine) and IIb (NNRTI without stavudine). A higher prevalence of lesions emerged in group Ia, while group IIa were at higher risk of developing vascular lesions than groups Ib and IIb. Conclusion: Although stavudine per se does not seem to determine damage of the epiaortic vessels, the association of a PI with stavudine is related to a significantly higher rate of lesions.