@article {MAGGI489, author = {PAOLO MAGGI and ANTONIO CHIRIANNI and ANTONIO LILLO and FRANCESCO PERILLI and MIRIAM GARGIULO and VINCENZO ESPOSITO and CHIARA BELLACOSA and GIUSEPPE PASTORE and GUIDO REGINA}, title = {A Color Doppler Ultrasound-based Comparative Study between Stavudine and Non-stavudine Regimens in the Onset of Vascular Lesions in HIV-1-positive Patients}, volume = {22}, number = {4}, pages = {489--492}, year = {2008}, publisher = {International Institute of Anticancer Research}, abstract = {Background: The present study aimed to investigate the role of stavudine in the onset of premature vascular lesions using an ultrasound color Doppler evaluation of the carotid vessels. Patients and Methods: A total of 266 patients were evaluated: 149 were treated with stavudine (group I) and 117 without stavudine (group II). Results: Of the patients in group I, 41\% exhibited vascular lesions vs. 26\% in group II (p=0.0103). The two groups were further divided into subgroups Ia (stavudine and proteinase inhibitor, PI), Ib (stavudine and non-nucleotidic reverse transcriptase inhibitor, NNRTI), IIa (PI, without stavudine) and IIb (NNRTI without stavudine). A higher prevalence of lesions emerged in group Ia, while group IIa were at higher risk of developing vascular lesions than groups Ib and IIb. Conclusion: Although stavudine per se does not seem to determine damage of the epiaortic vessels, the association of a PI with stavudine is related to a significantly higher rate of lesions.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/22/4/489}, eprint = {https://iv.iiarjournals.org/content/22/4/489.full.pdf}, journal = {In Vivo} }