TY - JOUR T1 - Antiviral, Antibacterial and Vitamin C-synergized Radical-scavenging Activity of <em>Sasa senanensis</em> Rehder Extract JF - In Vivo JO - In Vivo SP - 471 LP - 476 VL - 22 IS - 4 AU - HIROSHI SAKAGAMI AU - SHIGERU AMANO AU - HIROTAKA KIKUCHI AU - YUKIO NAKAMURA AU - REINA KUROSHITA AU - SHIGERU WATANABE AU - KAZUE SATOH AU - HIDEO HASEGAWA AU - AKIKO NOMURA AU - TAISEI KANAMOTO AU - SHIGEMI TERAKUBO AU - HIDEKI NAKASHIMA AU - SUMIKO TANIGUCHI AU - TAKAAKI OIZUMI Y1 - 2008/07/01 UR - http://iv.iiarjournals.org/content/22/4/471.abstract N2 - Sasa senanensis Rehder extract (SE) showed slightly higher cytotoxicity against human squamous cell carcinoma cell lines and human glioblastoma cell lines, as compared with human oral normal cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), and was more cytotoxic to human myelogenous and T-cell leukemia cell lines. SE showed a bacteriostatic effect on Fusobacterium nucleatum and Prevotella intermedia, but almost completely eliminated hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) produced by these bacteria. SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. SE also protected the MDCK cells from the cytopathic effect of influenza virus infection. SE synergistically enhanced the superoxide anion and hydroxyl radical-scavenging activity of vitamin C. The present study suggests the functionality of SE as a complementary alternative medicine. ER -