PT - JOURNAL ARTICLE AU - KRIENGSAK LIRDPRAPAMONGKOL AU - JAN-PETER KRAMB AU - DARANEE CHOKCHAICHAMNANKIT AU - CHANTRAGAN SRISOMSAP AU - RUDEE SURARIT AU - MONNIPHA SILA-ASNA AU - AHNOND BUNYARATVEJ AU - GERD DANNHARDT AU - JISNUSON SVASTI TI - Juice of <em>Eclipta prostrata</em> Inhibits Cell Migration <em>In Vitro</em> and Exhibits Anti-angiogenic Activity <em>In Vivo</em> DP - 2008 May 01 TA - In Vivo PG - 363--368 VI - 22 IP - 3 4099 - http://iv.iiarjournals.org/content/22/3/363.short 4100 - http://iv.iiarjournals.org/content/22/3/363.full SO - In Vivo2008 May 01; 22 AB - Background: The invasion of cancer cells is critical for metastasis. The effects of Eclipta prostrata, a Thai medicinal plant, on invasion, migration and adhesion of cancer cells were investigated and the anti-angiogenic activity in vivo was evaluated. Materials and Methods: In vitro invasion and migration assays were performed in modified Boyden chambers. In vivo anti-angiogenic activity was determined using the chick chorioallantoic membrane (CAM) assay. Results: E. prostrata juice inhibited cancer invasion and migration, without affecting cell adhesion. Cell migration was inhibited in a variety of cancer cell types and in endothelial cells, with IC50 values of 31-70 μg/ml, much lower than the IC50 values for cytotoxicity of 203-1,217 μg/ml for cancer cells and &gt;4,000 μg/ml for endothelial cells. Fifty percent inhibition of angiogenesis by E. prostrata juice was observed at 200 μg/egg. Conclusion: E. prostrata juice inhibited cancer and endothelial cell migration in vitro and also showed in vivo anti-angiogenic activity.