@article {LIRDPRAPAMONGKOL363, author = {KRIENGSAK LIRDPRAPAMONGKOL and JAN-PETER KRAMB and DARANEE CHOKCHAICHAMNANKIT and CHANTRAGAN SRISOMSAP and RUDEE SURARIT and MONNIPHA SILA-ASNA and AHNOND BUNYARATVEJ and GERD DANNHARDT and JISNUSON SVASTI}, title = {Juice of Eclipta prostrata Inhibits Cell Migration In Vitro and Exhibits Anti-angiogenic Activity In Vivo}, volume = {22}, number = {3}, pages = {363--368}, year = {2008}, publisher = {International Institute of Anticancer Research}, abstract = {Background: The invasion of cancer cells is critical for metastasis. The effects of Eclipta prostrata, a Thai medicinal plant, on invasion, migration and adhesion of cancer cells were investigated and the anti-angiogenic activity in vivo was evaluated. Materials and Methods: In vitro invasion and migration assays were performed in modified Boyden chambers. In vivo anti-angiogenic activity was determined using the chick chorioallantoic membrane (CAM) assay. Results: E. prostrata juice inhibited cancer invasion and migration, without affecting cell adhesion. Cell migration was inhibited in a variety of cancer cell types and in endothelial cells, with IC50 values of 31-70 μg/ml, much lower than the IC50 values for cytotoxicity of 203-1,217 μg/ml for cancer cells and \>4,000 μg/ml for endothelial cells. Fifty percent inhibition of angiogenesis by E. prostrata juice was observed at 200 μg/egg. Conclusion: E. prostrata juice inhibited cancer and endothelial cell migration in vitro and also showed in vivo anti-angiogenic activity.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/22/3/363}, eprint = {https://iv.iiarjournals.org/content/22/3/363.full.pdf}, journal = {In Vivo} }