PT  - JOURNAL ARTICLE
AU  - HORIE, NORIO
AU  - HASHIMOTO, KEN
AU  - KATO, TAKAO
AU  - SHIMOYAMA, TETSUO
AU  - KANEKO, TADAYOSHI
AU  - KUSAMA, KAORU
AU  - SAKAGAMI, HIROSHI
TI  - COX-2 as Possible Target for the Inhibition of PGE<sub>2</sub> Production by <em>Rikko-san</em> in Activated Macrophage
DP  - 2008 May 01
TA  - In Vivo
PG  - 333--336
VI  - 22
IP  - 3
4099  - http://iv.iiarjournals.org/content/22/3/333.short
4100  - http://iv.iiarjournals.org/content/22/3/333.full
SO  - In Vivo2008 May 01; 22
AB  - We have previously reported that Rikko-san (RKS) inhibited the lipopolysaccharide (LPS)-stimulated prostaglandin (PG) E2 in mouse macrophage-like RAW264.7 cells without affecting the expression of cyclooxygenase (COX)-2. Here RKS inhibition of the enzyme activity of both COX-1 and COX-2 proteins was investigated. Western blot analysis showed that RKS did not significantly change the S-nitrosylated COX-2 protein level. On the other hand, RKS inhibited the PG production catalyzed by purified COX-2, more effectively than that catalyzed by purified COX-1. These results suggest that RKS inhibits the PGE2 production by selectively inhibiting the COX-2 activity in activated macrophages.