PT  - JOURNAL ARTICLE
AU  - MAREK CEGIELSKI
AU  - ILONA IZYKOWSKA
AU  - MARZENA PODHORSKA-OKOLOW
AU  - MACIEJ ZABEL
AU  - PIOTR DZIEGIEL
TI  - Development of Foreign Body Giant Cells in Response to Implantation of Spongostan® as a Scaffold for Cartilage Tissue Engineering
DP  - 2008 Mar 01
TA  - In Vivo
PG  - 203--206
VI  - 22
IP  - 2
4099  - http://iv.iiarjournals.org/content/22/2/203.short
4100  - http://iv.iiarjournals.org/content/22/2/203.full
SO  - In Vivo2008 Mar 01; 22
AB  - Spongostan®, a gelatinous haemostatic sponge, is used in surgery. Moreover, Spongostan® may serve as a scaffold for proteins or cells implanted into defects. At the site of biomaterial implantation, foreign body giant cells (FBGCs) may develop which are responsible for Spongostan® degradation. The purpose of the present study was to examine whether Spongostan® may serve as a scaffold in allogenic grafting of chondrocytes developed from rabbit auricular cartilage. The obtained results indicate that Spongostan® fulfils its function as a cell scaffold, induces no inflammatory reaction and involves development of foreign body giant cells which participate in the process of its degradation. Microscopic observation showed that FBGCs manifest presence of cytoplasmic projections and lysosomes, which participate in phagocytosis of the applied scaffold. Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved