RT Journal Article SR Electronic T1 Successful Rescue of an Apocrine Gland Carcinoma Metastatic to the Cervical Lymph Nodes by Mitoxantrone Coupled with Trains of Permeabilizing Electrical Pulses (Electrochemotherapy) JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 51 OP 53 VO 22 IS 1 A1 ENRICO P. SPUGNINI A1 IVAN DOTSINSKY A1 NIKOLAY MUDROV A1 ANGELO DE LUCA A1 CARLO CODINI A1 GENNARO CITRO A1 ALFREDO D'AVINO A1 ALFONSO BALDI YR 2008 UL http://iv.iiarjournals.org/content/22/1/51.abstract AB Canine apocrine gland carcinoma is a locally aggressive neoplasm that can occasionally lead to metastatic spread, thus mimicking the behavior of their human counterpart. In this paper we describe the successful treatment of a cervical metastatic spread of this neoplasia by using mitoxantrone selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction from the first cycle of electrochemotherapy (ECT) and complete remission by the time of its fourth session. Neither systemic or local toxicities were detected during the whole course of therapy. The dog is in complete remission after six months from his last treatment. Electrochemotherapy is a safe and efficacious therapy for metastatic carcinoma and warrants further investigation. Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved