RT Journal Article
SR Electronic
T1 Changes of Glucocorticoid Receptor Expression in the Nasal Polyps of Patients with Chronic Sinusitis Following Treatment with Glucocorticoid
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 37
OP 42
VO 22
IS 1
A1 SO WATANABE
A1 HARUMI SUZAKI
YR 2008
UL http://iv.iiarjournals.org/content/22/1/37.abstract
AB Glucocorticoids (GCs) bind to the cellular glucocorticoid receptors (GRs) to exert anti-inflammatory and immunosuppressive actions. We investigated the changes in the expressions of the two GR isoforms, GR-α and GR-β, in nasal polyps treated with GC. Immunofluorescent staining revealed prominent expression of GR-α in the inflammatory cell infiltrate in the polyps obtained from patients with chronic sinusitis and bronchial asthma. Furthermore, while the expression of GR-α was significantly reduced following GC treatment, that of GR-β remained unchanged. The results of real-time PCR also revealed that the prominent expression of GR-α mRNA in the polyps decreased following GC treatment, while the expression of GR-β mRNA remained unchanged. The observations indicate that GR-α may play the major role in the inflammation associated with nasal polyps and the ratio of the expression level of GR-β to that of GR-α may serve as a useful index of the clinical efficacy of GC treatment. Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved