RT Journal Article SR Electronic T1 ACE Gene Variant Causing High Blood Pressure May Be Associated With Medication-related Jaw Osteonecrosis JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 559 OP 562 DO 10.21873/invivo.11510 VO 33 IS 2 A1 CHRISTOS YAPIJAKIS A1 VERONICA PAPAKOSTA A1 STAVROS VASSILIOU YR 2019 UL http://iv.iiarjournals.org/content/33/2/559.abstract AB The association of the high blood pressure D variant of the angiotensin-converting enzyme (ACE) gene with medication-related jaw osteonecrosis (MRONJ) is described in two Greek patients. The first patient, a 73-year-old man, took zolendronate, 4 mg/100 ml IV once per month for two years for prostate cancer and bone metastases. Three months after drug discontinuation, extraction of the first premolar was performed. After the intervention, he suffered from osteonecrosis of the mandible. He presented with hypertension and genetic testing revealed that he was homozygous for the high blood pressure D variant of the ACE gene. The second patient, a 65 years old woman, took denosumab, 120 mg subcutaneously once per month for 6 months for possible bone metastases from breast cancer. Three months after extraction of the first molar, she suffered from MRONJ. He also presented with hypertension and genetic testing revealed that she had the high blood pressure D variant of the ACE gene in a heterozygous state, which moderately predisposes to hypertension. To our knowledge, this is the first report indicating that genetic predisposition to hypertension may increase risk for MRONJ.