PT  - JOURNAL ARTICLE
AU  - MEEUS, MIRA
AU  - NIJS, JO
AU  - MCGREGOR, NEIL
AU  - MEEUSEN, ROMAIN
AU  - DE SCHUTTER, GUY
AU  - TRUIJEN, STEVEN
AU  - FRÉMONT, MARC
AU  - VAN HOOF, ELKE
AU  - DE MEIRLEIR, KENNY
TI  - Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity, and their Clinical Relevance
DP  - 2008 Jan 01
TA  - In Vivo
PG  - 115--121
VI  - 22
IP  - 1
4099  - http://iv.iiarjournals.org/content/22/1/115.short
4100  - http://iv.iiarjournals.org/content/22/1/115.full
SO  - In Vivo2008 Jan 01; 22
AB  - This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided. Copyright © 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved