<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">YAMAGUCHI, TOSHIFUMI</style></author><author><style face="normal" font="default" size="100%">YOSHIDA, MOTOKI</style></author><author><style face="normal" font="default" size="100%">TAIRA, KOICHI</style></author><author><style face="normal" font="default" size="100%">TOKUNAGA, SHINYA</style></author><author><style face="normal" font="default" size="100%">KATO, TAKESHI</style></author><author><style face="normal" font="default" size="100%">NAKAMURA, MASATO</style></author><author><style face="normal" font="default" size="100%">SUGIMOTO, NAOTOSHI</style></author><author><style face="normal" font="default" size="100%">FUMITA, SOICHI</style></author><author><style face="normal" font="default" size="100%">YASUI, MASAYOSHI</style></author><author><style face="normal" font="default" size="100%">MIYAKE, YASUHIRO</style></author><author><style face="normal" font="default" size="100%">KAWAKAMI, HISATO</style></author><author><style face="normal" font="default" size="100%">KUROKAWA, YUKINORI</style></author><author><style face="normal" font="default" size="100%">SHIMOKAWA, TOSHIO</style></author><author><style face="normal" font="default" size="100%">SATOH, TAROH</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Phase II Trial of Capecitabine Plus Bevacizumab for Elderly Patients With Metastatic Colorectal Cancer: OGSG 1102</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2025-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1505-1513</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/invivo.13950</style></doi><volume><style face="normal" font="default" size="100%">39</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: The combination of capecitabine and bevacizumab is a standard first-line chemotherapy regimen for vulnerable patients with unresectable colorectal cancer. However, the safety and efficacy of this regimen in Japanese patients have not been sufficiently investigated.Patients and Methods: This phase II study included patients aged ≥76 years or those aged 65-75 years who were unsuitable for intensive chemotherapy. Capecitabine at 2000 mg/m2/day (days 1-14) plus bevacizumab at 7.5 mg/kg (day 1) were administered every 3 weeks. The primary endpoint was progression-free survival. Secondary endpoints included overall survival, response rate, disease control rate, and toxicities.Results: Thirty-six patients were enrolled between July 2011 and July 2014, of whom 33 were included in the analysis. The median patient age was 78 years (range=67-86 years). A total of 28 patients had a performance status of 0 or 1, and five of 2. The median progression-free and overall survival were 10.3 (95% confidence interval=9.2-15.4) and 27.9 (95% confidence interval=24.2-50.1) months, respectively. The response and disease control rates were 30.3% and 91.0%, respectively. The major grade 3 or 4 toxicities were hypertension (n=12, 36%) and hand-foot syndrome (n=4, 12%). One patient experienced a grade 4 gastrointestinal perforation.Conclusion: The combination of capecitabine and bevacizumab demonstrated favorable efficacy and tolerability in Japanese patients with metastatic colorectal cancer who were unsuitable for intensive chemotherapy.</style></abstract></record></records></xml>