RT Journal Article
SR Electronic
T1 Intraarterial Hepatic Chemoembolization of Liver Metastases from Colorectal Cancer Adopting Irinotecan-eluting Beads: Results of a Phase II Clinical Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1085
OP 1091
VO 21
IS 6
A1 GIAMMARIA FIORENTINI
A1 CAMILLO ALIBERTI
A1 GINA TURRISI
A1 ALESSANDRO DEL CONTE
A1 SUSANNA ROSSI
A1 GIORGIO BENEA
A1 PETROS GIOVANIS
YR 2007
UL http://iv.iiarjournals.org/content/21/6/1085.abstract
AB Since November 2005 a clinical trial of intraarterial hepatic chemoembolization (TACE) with irinotecan-eluting beads has been ongoing in 20 patients affected by liver metastases from colorectal cancer in a palliative setting. A high response rate (80%), with reduction of lesional contrast enhancement in all responding patients was found. The procedure was well tolerated by most patients, with a median duration of hospitalization of 3 days (range 1-10 days). The most important adverse event was abdominal pain during the injection. Adequate supportive treatment with antibiotic and antiemetic prophylaxis, dexamethasone, and intravenous hydration is strictly necessary until the serum levels of transaminases are stabilized and in order to prevent infections. Major analgesics such as morphine must be used before and after the procedure. Our results suggest that TACE using irinotecan-eluting beads is feasible and active in pretreated patients with liver metastases from CRC. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved