RT Journal Article
SR Electronic
T1 No Association with Risk for Colorectal Cancer of the Insertion/Deletion Polymorphism which Affects Levels of Angiotensin-converting Enzyme
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1065
OP 1068
VO 21
IS 6
A1 NIKOLAOS NIKITEAS
A1 CHRISTOS TSIGRIS
A1 AGAPI CHATZITHEOFYLAKTOU
A1 ATHANASIOS YANNOPOULOS
YR 2007
UL http://iv.iiarjournals.org/content/21/6/1065.abstract
AB Background: In the light of the established association of angiotensin-converting enzyme (ACE) with several types of cancer, the possible contribution of the insertion/deletion (I/D) polymorphism that affects ACE gene expression, in the development of colorectal cancer was investigated. Materials and Methods: DNA samples of 92 patients with colorectal cancer (adenocarcinomas) and 102 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis. The resulting allele and genotype frequencies of the patients were compared to those of the controls by Fischer's exact test and odds ratios. Results: No statistical differences were observed between healthy controls and patients with colorectal cancer regarding either genotype distribution or low expression I allele frequency. Conclusion: The ACE I/D polymorphism is not a genetic predisposing factor concerning the risk for colorectal cancer. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved