RT Journal Article SR Electronic T1 Effect of Topical Dexamethasone on Sensorineural Hearing Loss in Endotoxin-induced Otitis Media JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1043 OP 1047 VO 21 IS 6 A1 CHUL HO JANG A1 YONG BUM CHO A1 CHEOL HEE CHOI A1 SEE YOUNG PARK A1 SOK CHEON PAK YR 2007 UL http://iv.iiarjournals.org/content/21/6/1043.abstract AB Sensorineural hearing loss, which is limited to the cochlear basal turn, due to acute or chronic otitis media has been reported in clinical and experimental studies. In the present study, the effect of intratympanic dexamethasone on endotoxin-induced cochlear damage was investigated by measuring the cochlear blood flow and hearing. Materials and Methods: Ten male Sprague-Dawley rats were inoculated with lipopolysaccharide (LPS), and divided into 2 groups of five rats each. One hour after intratympanic inoculation, the group A received 40 μl of phosphate-buffered saline (PBS) in the right middle ear cavity, group B received 40 μl of dexamethasone. The treated animals were examined 24 h after inoculation using auditory brainstem response (ABR) and cochlear blood flow (CBF). Results: The elevated threshold decreased significantly after intratympanic dexamethasone administration compared to the PBS-treated group. Intratympanic dexamethasone administration to the round window of rats led to a statistically significant increase in CBF compared to the PBS-treated group (p<0.05). The response to round window application of prostaglandin E1 (PGE1) in the dexamethasone-treated group was better than in the PBS-treated group. Conclusion: Our results showed that intratympanic dexamethasone treatment was effective in protecting the function of the cochlea against endotoxin-induced otitis media. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved