PT  - JOURNAL ARTICLE
AU  - KYUNG MI SHIM
AU  - SEOK HWA CHOI
AU  - MOON-JIN JEONG
AU  - SEONG SOO KANG
TI  - Effects of Aucubin on the Healing of Oral Wounds
DP  - 2007 Nov 01
TA  - In Vivo
PG  - 1037--1041
VI  - 21
IP  - 6
4099  - http://iv.iiarjournals.org/content/21/6/1037.short
4100  - http://iv.iiarjournals.org/content/21/6/1037.full
SO  - In Vivo2007 Nov 01; 21
AB  - Aucubin is an iridoid glycoside with a variety of pharmacological effects, such as antimicrobial and anti-inflammatory, whilst also promoting dermal wound healing. This study examined the effects of 0.1% aucubin on oral wound healing. ICR male mice were divided into two groups: an untreated control group (n=18) and an aucubin-treated group (n=18). Saline or 0.1% aucubin solution was injected and artificial full thickness wounds were made on either side of the buccal mucosa. Specimens were taken on days 1, 3 and 5, and light microscopic examination and quantitative histological analysis were performed to determine the extent of re-epithelization, inflammatory cell infiltration and matrix formation. Re-epithelization and matrix formation of the aucubin-treated group occurred earlier than that of the control group. In addition, the number of inflammatory cells of the aucubin-treated group was fewer than that of the control group. In conclusion, aucubin may be useful for oral wound healing and can be applied as a topical agent to oral wounds. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved