<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">YANNOPOULOS, ATHANASIOS</style></author><author><style face="normal" font="default" size="100%">NIKITEAS, NIKOLAOS</style></author><author><style face="normal" font="default" size="100%">CHATZITHEOFYLAKTOU, AGAPI</style></author><author><style face="normal" font="default" size="100%">TSIGRIS, CHRISTOS</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">The (-590 C/T) Polymorphism in the Interleukin-4 Gene is Associated with Increased Risk for Early Stages of Corolectal Adenocarcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1031-1035</style></pages><volume><style face="normal" font="default" size="100%">21</style></volume><issue><style face="normal" font="default" size="100%">6</style></issue><abstract><style  face="normal" font="default" size="100%">Background: In the light of the known association between several carcinomas and the -590C/T polymorphism, which affects transcription of the antitumor interleukin-4 (IL-4) gene, the purpose of this study was to investigate the possible contribution of this polymorphism to the development of colorectal cancer. Materials and Methods: The -590C/T polymorphism was examined in DNA samples of 93 patients with colorectal cancer (adenocarcinomas) and 108 healthy controls of comparable ethnicity, age and gender. Results: The detected allele and carrier frequencies for the high expression T allele in the patient group were significantly decreased in comparison with that of the control group (13.44% versus 22.22%, and 21.51% versus 36.11%, respectively, p&lt;0.01). The same pattern was observed between controls and patients in initial cancer stages. Conclusion: These findings indicate that IL-4 gene expression-related polymorphism is associated with the development of initial stages of colorectal cancer, while in advanced stages IL-4 levels appear to be less important. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>