TY - JOUR T1 - Diabetes does not Influence Oral Oncogenesis Through Fibroblast Growth Factor Receptors JF - In Vivo JO - In Vivo SP - 623 LP - 628 VL - 21 IS - 4 AU - ELEFTHERIOS VAIRAKTARIS AU - LAMBROS GOUTZANIS AU - EMEKA NKENKE AU - SOFIA SPYRIDONIDOU AU - STAVROS VASSILIOU AU - SPYRIDOULA DERKA AU - ANTONIS VYLLIOTIS AU - CHRISTOS YAPIJAKIS AU - ANDREAS LAZARIS AU - PASHALIS STRANTZIAS AU - ELEFTHERIOS KALIMERAS AU - EFSTRATIOS PATSOURIS Y1 - 2007/07/01 UR - http://iv.iiarjournals.org/content/21/4/623.abstract N2 - Background: Increased expression of fibroblast growth factors and their receptors (FGFRs) has recently been described in oral squamous cell carcinoma. In addition, we have previously described a molecular basis for an association between oral cancer and diabetes. The expression of FGFR-2 and FGFR-3 investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) rats. Materials and Methods: Tissue sections ranging from normal mucosa to moderately-differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins. Results: A similar pattern of elevated FGFR-2 and FGFR-3 expression was observed in the initial stages of oncogenesis for both diabetic and non-diabetic animals. In the last stages of oral oncogenesis, the expression of both proteins remained relatively stable. Conclusion: It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -