RT Journal Article
SR Electronic
T1 Diabetes Increases both N-ras and Ets-1 Expression During Rat Oral Oncogenesis Resulting in Enhanced Cell Proliferation and Metastatic Potential
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 615
OP 621
VO 21
IS 4
A1 ELEFTHERIOS VAIRAKTARIS
A1 LAMBROS GOUTZANIS
A1 GIORGOS KALOKERINOS
A1 ATHANASIOS YANNOPOULOS
A1 CHRISTOS YAPIJAKIS
A1 STAVROS VASSILIOU
A1 SOFIA SPYRIDONIDOU
A1 ANTONIS VYLLIOTIS
A1 EMEKA NKENKE
A1 ANDREAS C. LAZARIS
A1 CHRISTINA TESSEROMATIS
A1 EFSTRATIOS PATSOURIS
YR 2007
UL http://iv.iiarjournals.org/content/21/4/615.abstract
AB Background: The expression of N-ras and ets-1 proteins was investigated in an experimental model of chemically-induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats. Materials and Methods: Tissue sections ranging from normal mucosa to moderately-differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against N-ras and ets-1 proteins. Results: In diabetic rats, N-ras expression increased with tumor advancement, while in normal rats N-ras was not detected in initial stages of oral oncogenesis and increased only in well-differentiated OSCC. The same pattern of elevated ets-1 expression was observed both in diabetic and normal rats, but in cancerous stages this expression was higher in diabetic than in normal rats. Conclusion: It seems that diabetes may contribute to increased cell proliferation due to N-ras constitutive activation, as well as to enhanced invasion and metastatic potential by increasing ets-1 levels. Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved