RT Journal Article
SR Electronic
T1 Multidrug Resistance Reversal by 3-Formylchromones in Human Colon Cancer and Human <em>mdr1</em> Gene-transfected Mouse Lymphoma Cells
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 645
OP 649
VO 20
IS 5
A1 BARÁTH, ZOLTÁN
A1 RADICS, RITA
A1 SPENGLER, GABRIELLA
A1 OCSOVSZKI, IMRE
A1 KAWASE, MASAMI
A1 MOTOHASHI, NOBORU
A1 SHIRATAKI, YOSHIAKI
A1 SHAH, ANAMIK
A1 MOLNÁR, JÓZSEF
YR 2006
UL http://iv.iiarjournals.org/content/20/5/645.abstract
AB Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved