PT  - JOURNAL ARTICLE
AU  - BARÁTH, ZOLTÁN
AU  - RADICS, RITA
AU  - SPENGLER, GABRIELLA
AU  - OCSOVSZKI, IMRE
AU  - KAWASE, MASAMI
AU  - MOTOHASHI, NOBORU
AU  - SHIRATAKI, YOSHIAKI
AU  - SHAH, ANAMIK
AU  - MOLNÁR, JÓZSEF
TI  - Multidrug Resistance Reversal by 3-Formylchromones in Human Colon Cancer and Human <em>mdr1</em> Gene-transfected Mouse Lymphoma Cells
DP  - 2006 Sep 01
TA  - In Vivo
PG  - 645--649
VI  - 20
IP  - 5
4099  - http://iv.iiarjournals.org/content/20/5/645.short
4100  - http://iv.iiarjournals.org/content/20/5/645.full
SO  - In Vivo2006 Sep 01; 20
AB  - Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved